Commonly used JEV vaccines are mouse brain, cell culture derived live attenuated and inactivated. Safe and effective vaccines in use in the last three decades are formalin inactivated[1]. The only World Health Organization (WHO) approved JEV vaccines is the mouse brain inactivated processed by Beijing_1 and Nakayama strains[2]. Other vaccines in use are protein based, recombinant virus and DNA vaccines.
Protein vaccines produce protective immunity through receptor binding of the virus[3]. Currently DNA vaccines are recommended for their ability to develop a wide range of immune responses like antibodes, CD8 cyctotoxic lymphocytes and CD4 helper.
[1] Saxena and Dhole, Preventive Strategies, 507.
[2] Solomon, et al., Japanese Encephalitis, 415.
[3] Tiroumourougane, et al., Japaneseviral Encephalitis, 208.
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